Systems Biology: Constraint-based Reconstruction and Analysis Bernhard O. Palsson is an English-language textbook aimed at professionals in the life sciences. This book covers the methods for reconstructing and analyzing biological systems at genome scale.
This edition describes the construction of quantitative, computationally tractable genotype–phenotype relationships based on genome-scale biochemical reaction networks. It provides a clear explanation of how biological knowledge is brought together to reconstruct biochemical reaction systems and how these models can be used to address fundamental biological questions.
This textbook explains how computational models of biological functions are formulated and applied for predictive biology. Developed for intensive teaching, it provides students and professionals with a solid conceptual framework and practical modeling tools.
It is the first complete, single-author book devoted to genome-scale models and the bottom-up approach within systems biology.
Topics connect to the Life Sciences, including general issues and biochemical reaction networks.